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The Cytogenomics Array Group (CAG) began as an informal network of colleagues in North and South Carolina (originally the "Carolinas Array Group") formed to exchange information between laboratories regarding constitutional microarrays and rare case findings. In order to facilitate this exchange, we created a web-accessible database (CAGdb) to house each laboratory’s abnormal cases, which could then be freely shared in a de-identified fashion with all participating laboratories. CNV details, interpretation comments, parental and other follow-up data, and clinical features (all fully stripped of patient identifiers) are collected and shared for each case in this site. This database provides a useful laboratory tool to track experience with in-house microarray cases, network with colleagues, and to share experience with rare findings. Additionally, this resource is meant to facilitate submission to other larger-scale data collections in order to aid in syndrome discovery efforts and make information on rare cases more broadly available. Participating laboratories are encouraged to submit data to NCBI’s ClinVar project (http://www.ncbi.nlm.nih.gov/clinvar/) through the ISCA data collection (http://www.iscaconsortium.org/). With laboratory permission, all cases, or any subset of selected cases, in the CAGdb will be reformatted and submitted to NCBI on that laboratory’s behalf. We encourage participation from any interested laboratories and invite suggestions for improvement of the functionality of the project. This is operated as a non-profit resource through the Mission Healthcare Foundation and is freely available to all participants.
For more information about participation in the Cytogenomics Array Group and this database, please contact the site administrator (currently Dr. Hutton Kearney, Fullerton Genetics Center/Mission Health) at the following address: .
Swissotel, Chicago, Illinois
The Cancer Cytogenomics Microarray Consortium (CCMC) has scheduled its 4th summer meeting which will be held in conjunction with the Cytogenomics Array Group (CAGdb) meeting. The joint conference will be held at the Swissotel in Downtown Chicago on August 5-7, 2013.
The first half of the meeting will be devoted to cancer-related topics and will include invited presentations from leading cancer geneticists/genomicists, focusing on the clinically important as well as recent developments in cancer genomic diagnosis, prognosis, and management. The Key Note Address entitled "Evolving technologies for cancer diagnostics" will be delivered by Dr. Timothy Ley from the Genome Institute at Washington University. Dr. Ley is a hematologist, oncologist & cancer biologist and is internationally recognized as an expert in the pathogenesis of acute myeloid leukemia (AML) and other blood-related disorders.
The second half of the meeting will focus on constitutional microarray analysis with various workshops planned for data interpretation, information sharing, database building and best practices in reporting and follow-up. Dr. David Miller from Boston Children’s Hospital will give the Key Note Address entitled "Constitutional Array CGH: Looking Back and Looking Ahead". Dr. Miller is a medical geneticist and clinical molecular geneticist and an Assistant Professor of Pediatrics at Harvard Medical School. Dr. Miller has authored several key publications in the field of medical genetics and genetic testing, more recently focusing on the clinical value and utility of genetic testing.
The mid-portion of the meeting (afternoon of Day 2) will cover practical topics that relate to both cancer and constitutional diagnostics such as microarray data quality metrics. Additionally, we are providing an optional short workshop at the end of the meeting for any attendees new to microarray analysis or desiring a hands-on interactive session for microarray interpretation. During this 2 ½ hour final session, we will review useful databases and provide hands-on demonstrations for microarray interpretations. Prior to the meeting, we will poll attendees for interest and desired topic coverage for this session.
Abstracts will only be presented in the first half of the meeting and therefore submissions should focus on cancer-related topics. The deadline for abstract submission is April 22, 2013. All abstracts will be published in the journal Cancer Genetics.
For meeting/hotel registration and abstract submission, go to www.cancergenomics.org - CCMC »
We look forward to seeing you in Chicago.
Renaissance Asheville Hotel, Asheville North Carolina